Pcb.

(Each entry is one finding in the study if ---

otherwise stated. Some studies have several conclusions.)

All 23 studies described below showed some aspects of the immune system

disorders caused by the influence of PCB. Keep in mind that not all research

equal size and quality. Some study the influence of the old commercial PCB mixtures

(which are of variable composition), or just one or two separate >> << types of printed circuit boards (of 209 possible). This explains some of the differences

results. It is clear that not all PCB have the same effect, and only some are

imunnotoksicheskogo. Some of these studies from the 1970s, when scientists

was simply to learn about the immune effects. Some studies using high and some

using low doses of PCBs. In some cases, the exact dose fee was not known.

Types of printed circuit boards, which stayed in our region and accumulated in the Fox River

and Green Bay fish are likely to be more persistent and toxic payment type. background levels of PCBs / dioxins affect the human fetus and newborn

immune system. (2 studies)

increased number of CD8 + (cytotoxic), TCR alpha beta + gamma and delta TCR

+ T cells

45. 6% fee poisoning patients showed anti-nuclear antibodies, 12. 7% of rheumatoid

(arthritis) and 11 factor. 1% of thyroglobulin antibody

serum immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin

M (IgM) were raised to 12. 7% 24. 1% and 8. 9% in PCB poisoning

patients thyroglobulin antibodies were found in 19. 5% of people with higher fees

impact of dioxins and related compounds may be associated with immunopathy, such as atopic dermatitis

PCB poisoning of children suffer higher rates bronchitis, respiratory tract

and ear infections and flu Attacks

immune function tests may be necessary to detect changes (eg, delayed hypersensitivity reaction

skin, in vitro propagation of lymphocytes and antibody

synthesis after immunization)

organochlorine compounds, as reported negatively affect the human immune system

, reducing the protection from cancer

, worsening respiratory symptoms associated with exposure to PCB poisoning people

along with viral or bacterial infections

immunoglobulin A and immunoglobulin M levels were reduced, and immunoglobulin G

level was increased

percentage of the total number of T cells, active T cells and decreased cell TMU (2

research)

decreased percentage of total T lymphocytes, active T cells and helper T cells

platelet aggregation, serotonin release and 12-noetherian form

increase readiness for allergic respiratory disease through proof

hyperreactive with mucous membranes

PCB 126 (dioksinopodobnyh PCB) did not kill monocytes but strongly induced

CYP 1A1 in human hepatoma Hep G2 cells

direct effect on lymphocytes, for example , interference epitopes

CD 2-receptors or membrane function tests

was created for selective identification and quantitative determination of PCBs 77, 126 and 169

(each entry is one of the conclusions in study if ---

otherwise stated. Some studies have several conclusions.)

All but one of 45 reviews below show that PCBs are believed to be toxic

for at least Some parts of the immune system. No "safe" level of exposure to PCBs --- any effects PCBs may bear

risk, no matter how small exhibition

dioxins and dioxin-like chemicals (PCBs) present in the environment,

food chain and body tissues at doses or near levels to cause harm >>

<< public health achievement for human consumption close to zero, PCBs will require significant ban

products such as fish

Dioxin is the common name for a series of 75 dibenzodioxins, 135 dibenzofurans

and 209 PCB. damage to the immune system are more dramatic and resistant PCB fruit

and children, in contrast to the PCB exposed adults (2 studies)

immunity and immunosuppression equal decreased resistance to viral,

bacterial, fungal and other infectious agents or increased susceptibility to cancer >> << apoptosis can lead to a change in the ratio of cell loss of tuberculosis and regulations >> << cells in critical numbers leads to disturbances in immune functions

compromised lasix mg iv immune system can disrupt other vital systems for

early development in the womb or childhood

payment of industrial mix is ​​different from the composition of PCB mixtures

which people are exposed to, especially with food

some PCBs bind Ah receptor body, which is associated with the immune system

except sensitization, most effects observed in Boards

animals until there is in humans (1988)

impact of many chemicals or their metabolites in immune function is

through their direct influence or lymphoid tissue. In 1974, scientists had signs of PCB causes the immune system

damage to a number of printed circuit boards (flat and mono-ortho planar PCBs) cause effects

correspondence with those from 2.3 ,7,8-PCDD (dioxins) and PCDFs (furyl)

Research immune produce different results, using a wide range of events

chemical effects can lead to immunosuppression, immunopotentiation, hypersensitivity or perturbed

innate resistance to immunological effects have been demonstrated in people, but data so far

not allow quantitative conclusions. In the absence of quantitative data

research on humans, the risk assessment should be

on the basis of experimental data on animal

responses in the human population is heterogeneous (each of us different genetic susceptibility

because each of us react differently) << >> levels of influence is often low (which can make the effect more subtle, rare >> << or difficult to detect) . << >>